Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris.

ABSTRACT: Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms underpin this fluconazole resistance. To identify novel mechanisms contributing to fluconazole resistance in C. auris, fluconazole-susceptible C. auris clinical isolate AR0387 was passaged in media supplemented with fluconazole to generate derivative strains which had acquired increased fluconazole resistance in vitro Comparative analyses of comprehensive sterol profiles, [³H]fluconazole uptake, sequencing of C. auris genes homologous to genes known to contribute to fluconazole resistanc

SUBMITTER: Rybak JM 

PROVIDER: S-EPMC7218281 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature