Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells.

ABSTRACT: The pharmacodynamic interactions among trifluoperazine (TFP), gemcitabine (GEM), and paclitaxel (PTX) were assessed in pancreatic cancer cells (PANC-1). The phenothiazine TFP was chosen for its potential activity on cancer stem cells, while GEM and PTX cause apoptosis. Effects of each drug alone and in various combinations on cell growth inhibition of PANC-1 cells were studied in vitro to determine the drug-specific parameters and assess the nature of drug interactions. Joint inhibition (JI) and competitive inhibition (CI) equations were applied with a ψ interaction term. TFP fully inhibited growth of cells (I_max = 1) with an IC₅₀ = 9887 nM. Near-maximum inhibition was achieved for GEM (I_max = 0.825) and PTX (I_max= 0.844) with an IC₅₀ 

SUBMITTER: Molins EAG 

PROVIDER: S-EPMC7218410 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature