Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes.

ABSTRACT: Membrane attack complexes (MACs; C5b-9) assembled after complement activation can directly injure self-tissues, leading to various diseases. Eculizumab, a monoclonal antibody (mAb) against complement component C5, is being used in the clinic to treat diseases in which MAC-mediated tissue damage is a primary cause. However, C5 is not a selective target for MAC assembly inhibition, and some patients respond incompletely or not at all to the eculizumab treatment. Therefore, C6, the next essential component in the terminal pathway of complement activation, may be an alternative target for the selective inhibition of MAC formation. Surprisingly, few reports describe a functional blockade of C6 using a specific mAb. Here, we report the development of an anti-human C6 mAb (clone 1C9) that recogni

SUBMITTER: Lin K 

PROVIDER: S-EPMC7218433 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature