Induction of blood-circulating bile acids supports recovery from myelosuppressive chemotherapy.

ABSTRACT: Chemotherapeutic agents can reduce bone marrow (BM) activity, causing myelosuppression, a common life-threatening complication of cancer treatment. It is challenging to predict the patients in whom prolonged myelosuppression will occur, resulting in a delay or discontinuation of the treatment protocol. An early indicator of recovery from myelosuppression would thus be highly beneficial in clinical settings. In this study, bile acids (BAs) were highly increased in the systemic circulation as a natural response during recovery from myelosuppression, supporting regeneration of BM cells. BA levels in the blood of pediatric cancer patients and mice treated with chemotherapeutic agents were increased, in synchrony with early proliferation of BM cells and recovery from myelosuppression. In a mous

SUBMITTER: Sigurdsson V 

PROVIDER: S-EPMC7218440 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature