The association of MEFV gene mutations with the disease risk and severity of systemic juvenile idiopathic arthritis.

ABSTRACT:

Background

Systemic juvenile idiopathic arthritis (sJIA) has many clinical features overlapping with familial Mediterranean fever (FMF), which is caused by mutations in MEFV gene. And FMF patients were easily misdiagnosed as sJIA in China. So we speculate that MEFV is critical genetic background for sJIA and influences patients' severity. In this study, we aim to figure out whether MEFV mutations are risk factor for the occurrence of sJIA and to study the association of MEFV mutations with disease severity of sJIA patients.

Methods

The present study includes 57 sJIA children and 2573 healthy controls. Odd ratio with 95% confidence interval based on allelic frequency of MEFV mutations or variants was used to evaluate their contribution to sJIA susceptibility. Meta-analysis wa

SUBMITTER: Zhong L 

PROVIDER: S-EPMC7218505 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature