Heterologous prime-boost: an important candidate immunization strategy against Tembusu virus.

ABSTRACT:

Background

Tembusu virus (TMUV), a newly emerging pathogenic flavivirus, spreads rapidly between ducks, causing massive economic losses in the Chinese duck industry. Vaccination is the most effective method to prevent TMUV. Therefore, it is urgent to look for an effective vaccine strategy against TMUV. Heterologous prime-boost regimens priming with vaccines and boosting with recombinant adenovirus vaccines have been proven to be successful strategies for protecting against viruses in experimental animal models.

Methods

In this study, heterologous and homologous prime-boost strategies using an attenuated salmonella vaccine and a recombinant adenovirus vaccine expressing prM-E or the E gene of TMUV were evaluated to protect ducks against TMUV infection for the first time, incl

SUBMITTER: Pan Y 

PROVIDER: S-EPMC7218524 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature