Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis.

ABSTRACT:

Background

Atherosclerosis is the main cause of cardiovascular diseases such as ischemic stroke and coronary heart disease. Gene-specific promoter methylation changes have been suggested as one of the causes underlying the development of atherosclerosis. We aimed to identify and validate specific genes that are differentially expressed through promoter methylation in atherosclerotic plaques. We performed the present study in four steps: (1) profiling and identification of gene-specific promoter methylation changes in atherosclerotic tissues; (2) validation of the promoter methylation changes of genes in plaques by comparison with non-plaque intima; (3) evaluation of promoter methylation status of the genes in vascular cellular components composing atherosclerotic plaques; and (4) e

SUBMITTER: Kim JY 

PROVIDER: S-EPMC7218560 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature