Association of human XPA rs1800975 polymorphism and cancer susceptibility: an integrative analysis of 71 case-control studies.

ABSTRACT:

Background

The objective of the present study is to comprehensively evaluate the impact of the rs1800975 A/G polymorphism within the human xeroderma pigmentosum group A (XPA) gene on susceptibility to overall cancer by performing an integrative analysis of the current evidence.

Methods

We retrieved possible relevant publications from a total of six electronic databases (updated to April 2020) and selected eligible case-control studies for pooled assessment. P-values of association and odds ratio (OR) were calculated for the assessment of association effect. We also performed Begg's test and Egger's test, sensitivity analysis, false-positive report probability (FPRP) analysis, trial sequential analysis (TSA), and expression/splicing quantitative trait loci (eQTL

SUBMITTER: Yuan M 

PROVIDER: S-EPMC7218628 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature