A luminal unfolding microneedle injector for oral delivery of macromolecules.

ABSTRACT: Insulin and other injectable biologic drugs have transformed the treatment of patients suffering from diabetes^1,2, yet patients and healthcare providers often prefer to use and prescribe less effective orally dosed medications^3-5. Compared with subcutaneously administered drugs, oral formulations create less patient discomfort⁴, show greater chemical stability at high temperatures⁶, and do not generate biohazardous needle waste⁷. An oral dosage form for biologic medications is ideal; however, macromolecule drugs are not readily absorbed into the bloodstream through the gastrointestinal tract⁸. We developed an ingestible capsule, termed the luminal unfolding microneedle injector, which allows for the oral delivery of biologic

SUBMITTER: Abramson A 

PROVIDER: S-EPMC7218658 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature