Glycosylated sphingolipids and progression to kidney dysfunction in type 1 diabetes.

ABSTRACT:

Background

Glycosphingolipids are important components of cell membranes, modulators of cell-cell interactions and cell recognition, and have recently emerged as bioactive molecules and important players in nearly all cell biological processes. We previously have shown that decreased plasma levels of long and very long species of ceramides were able to predict the development of macroalbuminuria (MA) in type 1 diabetes.

Objective

This study proposed to examine whether plasma glycosphingolipids could predict development of diabetic nephropathy, assessed as MA or chronic kidney disease (CKD).

Methods

Measurement of plasma hexosylceramides (H) and lactosylceramides (L) were conducted in the Lipidomics Core Facility of our Institution in a subcohort of 432 patients from t

SUBMITTER: Lopes-Virella MF 

PROVIDER: S-EPMC7218687 | biostudies-literature | 2019 May - Jun

REPOSITORIES: biostudies-literature