Impact of Self-Assembled Monolayer Design and Electrochemical Factors on Impedance-Based Biosensing.

ABSTRACT: Real-time sensing of proteins, especially in wearable devices, remains a substantial challenge due to the need to convert a binding event into a measurable signal that is compatible with the chosen analytical instrumentation. Impedance spectroscopy enables real-time detection via either measuring electrostatic interactions or electron transfer reactions while simultaneously being amenable to miniaturization for integration into wearable form-factors. To create a more robust methodology for optimizing impedance-based sensors, additional fundamental studies exploring components influencing the design and implementation of these sensors are needed. This investigation addresses a sub-set of these issues by combining optical and electrochemical characterization to validate impedance-based senso

SUBMITTER: Brothers MC 

PROVIDER: S-EPMC7218866 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature