Paternal Resistance Training Induced Modifications in the Left Ventricle Proteome Independent of Offspring Diet.

ABSTRACT: Ancestral obesogenic exposure is able to trigger harmful effects in the offspring left ventricle (LV) which could lead to cardiovascular diseases. However, the impact of the father's lifestyle on the offspring LV is largely unexplored. The aim of this study was to investigate the effects of 8 weeks of paternal resistance training (RT) on the offspring left ventricle (LV) proteome exposed to control or high-fat (HF) diet. Wistar rats were randomly divided into two groups: sedentary fathers and trained fathers (8 weeks, 3 times per week with weights secured to the animals' tails). The offspring were obtained by mating with sedentary females. Upon weaning, male offspring were divided into 4 groups (5 animals per group): offspring from sedentary fathers, exposed to control diet (SFO-C); offspr

SUBMITTER: de Sousa Neto IV 

PROVIDER: S-EPMC7218999 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature