Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study.

ABSTRACT:

Objective

Sex hormone-binding globulin (SHBG) and androgens have been associated with mortality in women and men, but controversy still exists. Our objective was to investigate associations of SHBG and androgens with all-cause and cause-specific mortality in men and women.

Design

1006 men and 709 peri- and postmenopausal women (age range: 45-82 years) from the German population-based KORA F4 cohort study were followed-up for a median of 8.7 years.

Methods

SHBG was measured with an immunoassay, total testosterone (TT) and dihydrotestosterone (DHT) with mass-spectrometry in serum samples and we calculated free testosterone (cFT). To assess associations between SHBG and androgen levels and mortality, we calculated hazard ratios (HRs) with 95% CIs using Cox proportional-h

SUBMITTER: Schederecker F 

PROVIDER: S-EPMC7219137 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature