Ewastools: Infinium Human Methylation BeadChip pipeline for population epigenetics integrated into Galaxy.

ABSTRACT:

Background

Infinium Human Methylation BeadChip is an array platform for complex evaluation of DNA methylation at an individual CpG locus in the human genome based on Illumina's bead technology and is one of the most common techniques used in epigenome-wide association studies. Finding associations between epigenetic variation and phenotype is a significant challenge in biomedical research. The newest version, HumanMethylationEPIC, quantifies the DNA methylation level of 850,000 CpG sites, while the previous versions, HumanMethylation450 and HumanMethylation27, measured >450,000 and 27,000 loci, respectively. Although a number of bioinformatics tools have been developed to analyse this assay, they require some programming skills and experience in order to be usable.

Results

W

SUBMITTER: Murat K 

PROVIDER: S-EPMC7219210 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature