Inhibition of K_Ca2 and K_v11.1 Channels in Pigs With Left Ventricular Dysfunction.

ABSTRACT:

Background

Inhibition of K_Ca2 channels, conducting I_KCa, can convert atrial fibrillation (AF) to sinus rhythm and protect against its induction. I_KCa inhibition has been shown to possess functional atrial selectivity with minor effects on ventricles. Under pathophysiological conditions with ventricular remodeling, however, inhibiting I_KCa can exhibit both proarrhythmic and antiarrhythmic ventricular effects. The aim of this study was to evaluate the effects of the I_KCa inhibitor AP14145, when given before or after the I_Kr blocker dofetilide, on cardiac function and ventricular proarrhythmia markers in pigs with or without left ventricular dysfunction (LVD).

Methods

Landrace pigs were randomized into an AF grou

SUBMITTER: Citerni C 

PROVIDER: S-EPMC7219273 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature