Cortical Thickness in Adolescents with a Family History of Alcohol Use Disorder.

ABSTRACT:

Background

Individuals with a family history (FH+) of alcohol use disorder (AUD) have a higher risk for developing an AUD than those with no family history (FH-) of AUD. In addition, FH+ individuals tend to perform worse on neuropsychological measures and show heightened impulsivity, which may be due to underlying differences in brain structure such as cortical thickness. The primary aim of this study was to investigate differences in cortical thickness in FH+ compared to FH- adolescents. Secondary aims were to (i) investigate differences in executive functioning and impulsivity, and (ii) examine associations between brain structure and behavior.

Methods

Brain scans of 95 FH- and 93 FH+ subjects aged 13 to 18 were obtained using magnetic resonance imaging. FH+ subjects were

SUBMITTER: Henderson KE 

PROVIDER: S-EPMC7219278 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature