Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis.

ABSTRACT: The etiology of myositis is unknown. Although attempts to identify viruses in myositis skeletal muscle have failed, several studies have identified the presence of a viral signature in myositis patients. Here we postulate that in individuals with susceptible genetic backgrounds, viral infection alters the epigenome to activate the pathological pathways leading to disease onset. To identify epigenetic changes, methylation profiling of Coxsackie B infected human myotubes and muscle biopsies from polymyositis (PM) and dermatomyositis (DM) patients were compared to changes in global transcript expression induced by in vitro Coxsackie B infection. Gene and protein expression analysis and live cell imaging were performed to examine the mechanisms. Analysis of methylation and gene expression chan

SUBMITTER: Boehler JF 

PROVIDER: S-EPMC7219509 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature