The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial.

ABSTRACT:

Objective

To determine whether antioxidants improve male fertility, as measured by semen parameters and DNA fragmentation at 3 months and pregnancy resulting in live birth after up to 6 months of treatment, among couples with male factor infertility.

Design

Multicenter, double-blind, randomized, placebo-controlled trial with an internal pilot study.

Setting

Nine fertility centers in the United States from December 2015 to December 2018.

Patient(s)

Men (N = 174) with sperm concentration ≤15 million/mL, motility ≤40%, normal morphology ≤4%, or DNA fragmentation >25%, and female partners who were ovulatory, ≤40 years old, and had documented tubal patency.

Intervention(s)

Males randomly assigned to receive an antioxidant formulation (n = 85) containing 500 m

SUBMITTER: Steiner AZ 

PROVIDER: S-EPMC7219515 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature