A Mathematical Model of Fluid Transport in an Accurate Reconstruction of Parotid Acinar Cells.

ABSTRACT: Salivary gland acinar cells use the calcium ([Formula: see text]) ion as a signalling messenger to regulate a diverse range of intracellular processes, including the secretion of primary saliva. Although the underlying mechanisms responsible for saliva secretion are reasonably well understood, the precise role played by spatially heterogeneous intracellular [Formula: see text] signalling in these cells remains uncertain. In this study, we use a mathematical model, based on new and unpublished experimental data from parotid acinar cells (measured in excised lobules of mouse parotid gland), to investigate how the structure of the cell and the spatio-temporal properties of [Formula: see text] signalling influence the production of primary saliva. We combine a new [Formula: see text] signallin

SUBMITTER: Vera-Siguenza E 

PROVIDER: S-EPMC7219794 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature