Fast pulsatile blood flow measurement in deep tissue through a multimode detection fiber.

ABSTRACT:

Significance

Noninvasive in vivo fast pulsatile blood flow measurement in deep tissue is important because the blood flow waveform is correlated with physiological parameters, such as blood pressure and elasticity of blood vessels. Compromised blood flow may cause diseases, such as stroke, foot ulcer, and myocardial ischemia. There is great clinical demand for a portable and cost-effective device for noninvasive pulsatile blood flow measurement.

Aim

A diffuse-optics-based method, diffuse speckle pulsatile flowmetry (DSPF), was developed for fast measurement (∼300  Hz) of deep tissue blood flow noninvasively. To validate its performance, both a phantom experiment and in vivo demonstration were conducted.

Approach

Over the past two decades, single-mode fibers have been

SUBMITTER: Bi R 

PROVIDER: S-EPMC7219964 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature