Versatile transgenic multistage effector-gene combinations for Plasmodium falciparum suppression in Anopheles.

ABSTRACT: The malaria parasite's complex journey through the Anopheles mosquito vector provides multiple opportunities for targeting Plasmodium with recombinant effectors at different developmental stages and different host tissues. We have designed and expressed transgenes that efficiently suppress Plasmodium infection by targeting the parasite with multiple independent endogenous and exogenous effectors at multiple infection stages to potentiate suppression and minimize the probability for development of resistance to develop. We have also addressed the fitness impact of transgene expression on the mosquito. We show that highly potent suppression can be achieved by targeting both pre-oocyst stages by transgenically overexpressing either the endogenous immune deficiency immune

SUBMITTER: Dong Y 

PROVIDER: S-EPMC7220273 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature