Potential mechanisms and serum biomarkers involved in sex differences in pulmonary arterial hypertension.

ABSTRACT: Pulmonary arterial hypertension (PAH) is a disease associated with high mortality, but notable sex differences have been observed between males and females. For this reason, further research on the mechanisms underlying sex differences in PAH is required to better understand and treat the disease. This study mainly focused on gene expression levels to investigate potential differences in the pathogenesis and progression of PAH between the male and female sexes.Sex-specific differentially expressed genes (DEGs) were analyzed using the Gene Expression Omnibus datasets GSE117261 and GSE38267. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted, and a protein-protein interaction (PPI) network was established based on the identified DEGs to pred

SUBMITTER: Li C 

PROVIDER: S-EPMC7220321 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature