Exploring immune-related genes with prognostic value in microenvironment of breast cancer from TCGA database.

ABSTRACT: Breast cancer is one of the most common malignancies in women worldwide. Many studies have shown that tumor microenvironment cells, immune cells, and stromal cell infiltration have an important impact on prognosis, so it is important to identify biomarkers for achieving better treatment and prognosis.To better understand the relationship between immune and stromal cell-related genes and prognosis, we screened patients with breast cancer in The Cancer Genome Atlas (TCGA) database and divided them into high and low groups based on immune/stromal scores. We next identified differentially expressed immune-related genes that are significantly associated with the prognosis of patients with breast cancer for functional enrichment analysis and protein-protein interaction networks, respectively. Fi

SUBMITTER: Yang H 

PROVIDER: S-EPMC7220520 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature