Bioinformatic identification of hub genes and key pathways in neutrophils of patients with acute respiratory distress syndrome.

ABSTRACT: Acute respiratory distress syndrome (ARDS) is characterized as a neutrophil-dominant disorder without effective pharmacological interventions. Knowledge of neutrophils in ARDS patients at the transcriptome level is still limited. We aimed to identify the hub genes and key pathways in neutrophils of patients with ARDS. The transcriptional profiles of neutrophils from ARDS patients and healthy volunteers were obtained from the GSE76293 dataset. The differentially expressed genes (DEGs) between ARDS and healthy samples were screened using the limma R package. Subsequently, functional and pathway enrichment analyses were performed based on the database for annotation, visualization, and integrated discovery (DAVID). The construction of a protein-protein interaction network was carried out usin

SUBMITTER: Hu L 

PROVIDER: S-EPMC7220668 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature