Temporal expression of cytokines and B-cell phenotypes during mechanical circulatory support.

ABSTRACT:

Background

Allosensitization during mechanical circulatory support (MCS) is a well-described phenomenon, although its mechanism remains unknown. Although immune-mediated interactions from devices or blood transfusions have been proposed, the role of inflammation in this development is less clear. This study was undertaken to further investigate the temporal association of cytokines and B-cell phenotypes in the MCS population.

Methods

Adult patients who received the Heartmate II (Thoratec, Pleasanton, Calif) at our center between September 2012 and March 2015 were prospectively followed after device implantation. Blood draws for anti-human leukocyte antigen (HLA) antibody, cytokine expression, and B-cell immunophenotyping were performed before implantation and for 3 weeks pos

SUBMITTER: Iyengar A 

PROVIDER: S-EPMC7220810 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature