Platelet-endothelial associations may promote cytomegalovirus replication in the salivary gland in mice.

ABSTRACT: Platelet decline is a feature of many acute viral infections, including cytomegalovirus (CMV) infection in humans and mice. Platelet sequestration in association with other cells, including endothelium and circulating leukocytes, can contribute to this decline and influence the immune response to and pathogenesis of viral infection. We sought to determine if platelet-endothelial associations (PEAs) contribute to platelet decline during acute murine CMV (mCMV) infection, and if these associations affect viral load and production. Male BALB/c mice were infected with mCMV (Smith strain), euthanized at timepoints throughout acute infection and compared to uninfected controls. An increase in PEA formation was confirmed in the salivary gland at all post-inoculation timepoints using immunohistoch

SUBMITTER: Braxton AM 

PROVIDER: S-EPMC7220825 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature