Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is a disease with variable morphology, clinical behaviour and response to therapy. Identifying factors associated with the progression of early-stage BC can help understand the risk of metastasis and guide treatment decisions. Myxovirus resistance 1 (MX1), which is involved in the cellular antiviral mechanism, plays a role in some solid tumours; however, its role in invasive BC remains unknown. In this study, we aimed to explore the clinicopathological and prognostic significance of MX1 in BC.

Methods

MX1 was assessed at the protein level using tissue microarrays from a large well-annotated BC cohort (n = 845). The expression of MX1 mRNA was assessed at the transcriptomic level using the Molecular Taxonomy of Breast Cancer International Consorti

SUBMITTER: Aljohani AI 

PROVIDER: S-EPMC7220876 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature