The role of the adaptor molecule STING during Schistosoma mansoni infection.

ABSTRACT: Schistosomiasis is a human parasitic disease responsible for serious consequences for public health, as well as severe socioeconomic impacts in developing countries. Here, we provide evidence that the adaptor molecule STING plays an important role in Schistosoma mansoni infection. S. mansoni DNA is sensed by cGAS leading to STING activation in murine embryonic fibroblasts (MEFs). Sting^-/- and C57BL/6 (WT) mice were infected with schistosome cercariae in order to assess parasite burden and liver pathology. Sting^-/- mice showed worm burden reduction but no change in the number of eggs or granuloma numbers and area when compared to WT animals. Immunologically, a significant increase in IFN-γ production by the spleen cells was observed in Sting^-/- animals. Surp

SUBMITTER: Souza C 

PROVIDER: S-EPMC7220917 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature