Real-World Evidence to Assess Medication Safety or Effectiveness in Children: Systematic Review.

ABSTRACT:

Background

The promise of real-world evidence (RWE) is especially relevant to pediatrics, where medicines prescribed for children are often used without evidence derived from randomized clinical trials.

Objectives

The aim of this systematic review was to describe the state of RWE in pediatrics by identifying observational studies published during 2016 that used RWE to assess medication safety or effectiveness in children.

Methods

An electronic search of PubMed was combined with an extended search of references within systematic reviews and expert suggestions. Studies were included if they reported on an infant or child under 18 years with exposure to medications; assessed safety or effectiveness; specified a comparison or control group, and were published in English i

SUBMITTER: Lasky T 

PROVIDER: S-EPMC7221095 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature