Assessment of Vancomycin Pharmacokinetics and Dose Regimen Optimisation in Preterm Neonates.

ABSTRACT:

Background

The pharmacokinetics of vancomycin, a drug used for the treatment of methicillin-resistant Staphylococcus aureus (MRSA), varies between paediatric and adult patients.

Objective

The objective of this study was to assess the pharmacokinetics of vancomycin in preterm neonates and determine the optimum dose regimen.

Methods

This was a randomised double-blind study of preterm neonates admitted to neonatal intensive care units. They all received vancomycin 15 mg/kg every 12 h. Blood was sampled just before administration of the third, sixth and ninth vancomycin dose. Pharmacokinetic parameters were estimated using a Bayesian approach implemented in Monolix 2018R2 software. Covariates assessed included postmenstrual age, current weight, creatinine clearance, album

SUBMITTER: Mulubwa M 

PROVIDER: S-EPMC7221111 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature