Biospeciation of Potential Vanadium Drugs of Acetylacetonate in the Presence of Proteins.

ABSTRACT: Among vanadium compounds with potential medicinal applications, [V^IVO(acac)₂] is one of the most promising for its antidiabetic and anticancer activity. In the organism, however, interconversion of the oxidation state to +III and +V and binding to proteins are possible. In this report, the transformation of V^III(acac)₃, V^IVO(acac)₂, and V^VO₂(acac) 2 - after the interaction with two model proteins, lysozyme (Lyz) and ubiquitin (Ub), was studied with ESI-MS (ElectroSpray Ionization-Mass Spectroscopy), EPR (Electron Paramagnetic Resonance), and computational (docking) techniques. It was shown that, in the metal concentration range close to that found in the organism (15-250 μM), V^III(acac)

SUBMITTER: Sciortino G 

PROVIDER: S-EPMC7221193 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature