Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk.

ABSTRACT:

Background

Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. insulin resistance and glucose homeostasis). Identification of interactions between variation in genes and these metabolic risk factors may identify novel biologic insights into CRC etiology.

Methods

To improve statistical power and interpretation for gene-environment interaction (G × E) testing, we tested genetic variants that regulate expression of a gene together for interaction with BMI (kg/m² ) and diabetes on CRC risk among 26 017 cases and 20 692 controls. Each variant was weighted based on PrediXcan analysis of gene expression data from colon tissue generated in the Genotype-Tissue Expression Project

SUBMITTER: Xia Z 

PROVIDER: S-EPMC7221445 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature