Prediagnostic adult body mass index change and esophageal adenocarcinoma survival.

ABSTRACT:

Background

We examined whether body mass index (BMI) changes in adulthood, prior to disease onset, are associated with overall survival among esophageal adenocarcinoma patients.

Methods

We included 285 histologically confirmed patients with a complete baseline BMI questionnaire. Using extended Cox regression models, we obtained adjusted hazard ratios (HRs) for the associations between overall survival and BMI at diagnosis, BMI 6 months before diagnosis, self-reported average adult BMI, and ΔBMI (BMI 6 months before diagnosis minus average adult BMI), categorized into tertiles <0 kg/m² (BMI loss), ≥0 and <1.25 kg/m² (stable BMI), and ≥1.25 kg/m² (BMI gain). We also assessed interaction between ΔBMI and average adult BMI (≥ kg/m² ver

SUBMITTER: Loehrer EA 

PROVIDER: S-EPMC7221446 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature