Modulation of the leptin receptors expression in breast cancer cell lines exposed to leptin and tamoxifen.

ABSTRACT: One of the factors that has increased the incidence and worse prognosis of breast cancer is obesity. In this condition, high amounts of leptin are secreted, which have proliferative, mitogenic, antiapoptotic, and proinflammatory activity that may be antagonistic to treatment with tamoxifen, considered the first choice. The modulation evaluation of leptin receptor expression in the presence of leptin and tamoxifen stimuli was performed in breast cancer cell lines MCF 7, MDA MB 231 and HCC 1937 as a model of initial approach for the study of breast cancer subtypes and their behavior to the action response of adipokines and their possible relationship with the mechanism of resistance to chemotherapeutics such as tamoxifen in ER positive cell lines and triple negative marker. It was determined

SUBMITTER: Linares RL 

PROVIDER: S-EPMC7222035 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature