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Junctional and somatic hypermutation-induced CX₄C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.

ABSTRACT: Induction of broadly neutralizing monoclonal antibodies (bNAbs) that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus (HCV) vaccine research. The study of bNAbs arising in natural infection is essential in this endeavor. We generated a human antibody, 8D6, recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient. This antibody shows broadly neutralizing activity, which covers a pan-genotypic panel of cell culture-derived HCV virions (HCVcc). Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2. We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization. We found that the V(D)J recombination-generated junctional

SUBMITTER: Yi C

PROVIDER: S-EPMC7222171 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Dataset Information

Junctional and somatic hypermutation-induced CX₄C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Junctional and somatic hypermutation-induced CX₄C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.