Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis.

ABSTRACT: The Cancer Genome Atlas (TCGA) and other large-scale genomic data pipelines have been integral to the current understanding of the molecular events underlying renal cell carcinoma (RCC). These data networks have focused mostly on primary RCC, which often demonstrates indolent behavior. However, metastatic disease is the major cause of mortality associated with RCC and data sets examining metastatic tumors are sparse. Therefore, a more comprehensive analysis of gene expression and DNA methylome profiling of metastatic RCC in addition to primary RCC and normal kidney was performed. Integrative analysis of the methylome and transcriptome identified over 30 RCC-specific genes whose mRNA expression inversely correlated with promoter methylation, including several known targets of hypoxia induci

SUBMITTER: Nam HY 

PROVIDER: S-EPMC7222224 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature