Predicting STAT1 as a prognostic marker in patients with solid cancer.

ABSTRACT:

Background

Aberrant activities of signal transducer and activator of transcription 1 (STAT1) have been implicated in cancer development. However, the prognostic value of STAT1 remains unclear. This report identified the role of STAT1 in prognosis in patients with solid cancer through open literature and The Cancer Genome Atlas (TCGA) database.

Methods

Published articles were obtained from PubMed, Web of Science, and Embase databases according to a search strategy up to October 2019. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted to assess the prognostic factors of patients. TCGA datasets were used to explore the prognostic value of STAT1 in various cancers.

Results

A total of 15 studies incorporating 2839 patients with solid cancers were

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7222261 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature