Pasireotide for acromegaly: long-term outcomes from an extension to the Phase III PAOLA study.

ABSTRACT:

Objective

In the Phase III PAOLA study (clinicaltrials.gov: NCT01137682), enrolled patients had uncontrolled acromegaly despite ≥6 months of octreotide/lanreotide treatment before study start. More patients achieved biochemical control with long-acting pasireotide versus continued treatment with octreotide/lanreotide (active control) at month 6. The current work assessed the extent of comorbidities at baseline and outcomes during a long-term extension.

Design/methods

Patients receiving pasireotide 40 or 60 mg at core study end could continue on the same dose in an extension phase if biochemically controlled or receive pasireotide 60 mg if uncontrolled. Uncontrolled patients on active control were switched to pasireotide 40 mg, with the dose increased at week 16 of the extens

SUBMITTER: Colao A 

PROVIDER: S-EPMC7222286 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature