Long-term exposure to particulate air pollution and brachial artery flow-mediated dilation in the Old Order Amish.

ABSTRACT:

Background

Atmospheric particulate matter (PM) has been associated with endothelial dysfunction, an early marker of cardiovascular risk. Our aim was to extend this research to a genetically homogenous, geographically stable rural population using location-specific moving-average air pollution exposure estimates indexed to the date of endothelial function measurement.

Methods

We measured endothelial function using brachial artery flow-mediated dilation (FMD) in 615 community-dwelling healthy Amish participants. Exposures to PM < 2.5 μm (PM_2.5) and PM < 10 μm (PM₁₀) were estimated at participants' residential addresses using previously developed geographic information system-based spatio-temporal models and normalized. Associations between PM exposures an

SUBMITTER: Salimi S 

PROVIDER: S-EPMC7222318 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature