Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.

ABSTRACT: Ageing is associated with disrupted redox signalling and increased circulating inflammatory cytokines. Skeletal muscle homeostasis depends on the balance between muscle hypertrophy, atrophy and regeneration, however during ageing this balance is disrupted. The molecular pathways underlying the age-related decline in muscle regenerative potential remain elusive. microRNAs are conserved robust gene expression regulators in all tissues including skeletal muscle. Here, we studied satellite cells from adult and old mice to demonstrate that inhibition of miR-21 in satellite cells from old mice improves myogenesis. We determined that increased levels of proinflammatory cytokines, TNFα and IL6, as well as H₂O₂, increased miR-21 expression in primary myoblasts, which in turn r

SUBMITTER: Borja-Gonzalez M 

PROVIDER: S-EPMC7222422 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature