Targeted imaging of orthotopic prostate cancer by using clinical transformable photoacoustic molecular probe.

ABSTRACT:

Background

To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as the gold standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imaging strategy using a real-time molecular photoacoustic imaging system integrated with a handheld US probe (PAI/US) and synthesized an integrin α_vβ₃ targeted probe based on ICG (cRGD-ICG).

Methods

To prepare cRGD-ICG, ICG-NHS was linked to cRGD through carboxyl-co-reaction. In vitro PA imaging ability of cRGD-ICG was tested. Orthotopic PCa-bearing rats were used as animal models. After injected with either cRGD-ICG or non-targeted probe, rat

SUBMITTER: Qiu C 

PROVIDER: S-EPMC7222516 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature