Comparative Analysis of CpG Sites and Islands Distributed in Mitochondrial DNA of Model Organisms.

ABSTRACT: : The information about mtDNA methylation is still limited, thus epigenetic modification remains unclear. The lack of comprehensive information on the comparative epigenomics of mtDNA prompts comprehensive investigations of the epigenomic modification of mtDNA in different species. This is the first study in which the theoretical CpG localization in the mtDNA reference sequences from various species (12) was compared. The aim of the study was to determine the localization of CpG sites and islands in mtDNA of model organisms and to compare their distribution. The results are suitable for further investigations of mtDNA methylation. The analysis involved both strands of mtDNA sequences of animal model organisms representing different taxonomic groups of invertebrates and vertebrates. For eac

SUBMITTER: Kowal K 

PROVIDER: S-EPMC7222804 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature