Diagnosis and Management of Tuberculous Pericarditis: What Is New?

ABSTRACT:

Purpose of review

This review provides an update on the immunopathogenesis of tuberculous pericarditis (TBP), investigations to confirm tuberculous etiology, the limitations of anti-tuberculous therapy (ATT), and recent efficacy trials.

Recent findings

A profibrotic immune response characterizes TBP, with low levels of AcSDKP, high levels of γ-interferon and IL-10 in the pericardium, and high levels of TGF-β and IL-10 in the blood. These findings may have implications for future therapeutic targets. Despite advances in nucleic acid amplification approaches, these tests remain disappointing for TBP. Trials of corticosteroids and colchicine have had mixed results, with no impact on mortality, evidence of a reduction in rates of constrictive pericarditis and potential harm in t

SUBMITTER: Isiguzo G 

PROVIDER: S-EPMC7222865 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature