Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's disease.

ABSTRACT:

Background

Non-motor symptoms (NMS) are common in Parkinson's disease (PD), but their relationships to nigrostriatal degeneration remain largely unexplored.

Methods

We evaluated 18 NMS scores covering 5 major domains in relation to concurrent and future dopamine transporter (DAT) imaging in 344 PD patients from the Parkinson's Progression and Markers Initiative (PPMI). We standardized NMS assessments into z-scores for side-by-side comparisons. Patients underwent sequential DaTSCAN imaging at enrollment and at months 12, 24, and 48. Specific binding ratios (SBR) were calculated using the occipital lobe reference region. We evaluated the association of striatal DAT binding at the four time points with each baseline NMS using mixed-effects regression models.

Results

Mult

SUBMITTER: Liu R 

PROVIDER: S-EPMC7222918 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature