New markers for sepsis caused by Pseudomonas aeruginosa during burn infection.

ABSTRACT:

Introduction

Sepsis is a leading cause of mortality in burn patients. One of the major causes of sepsis in burn patients is Pseudomonas aeruginosa. We hypothesized that during dissemination from infected burn wounds and subsequent sepsis, P. aeruginosa affects the metabolome of the blood resulting in changes to specific metabolites that would serve as biomarkers for early diagnosis of sepsis caused by P. aeruginosa.

Objectives

To identify specific biomarkers in the blood after sepsis caused by P. aeruginosa infection of burns.

Methods

Gas chromatography with time-of-flight mass spectrometry was used to compare the serum metabolome of mice that were thermally injured and infected with P. aeruginosa (B-I) to that of mice that were neither injured nor infected, mice that

SUBMITTER: Elmassry MM 

PROVIDER: S-EPMC7223005 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature