Causal associations of insulin resistance with coronary artery disease and ischemic stroke: a Mendelian randomization analysis.

ABSTRACT:

Introduction

The relationship between insulin resistance (IR) and cardiovascular diseases is unclear. We aimed to examine the causal associations of IR with cardiovascular diseases, including coronary artery disease, myocardial infarction, ischemic stroke and its subtypes, using Mendelian randomization.

Research design and methods

Due to low sample size for gold standard measures and in order to well reflect the underlying phenotype of IR, we used 53 single nucleotide polymorphisms associated with IR phenotypes (ie, fasting insulin, high-density lipoprotein cholesterol and triglycerides) from recent genome-wide association studies (GWASs) as instrumental variables. Summary-level data from four GWASs of European individuals were used. Data on IR phenotypes were obtained from

SUBMITTER: Chen W 

PROVIDER: S-EPMC7223029 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature