Streptovertimycins A-H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain.

ABSTRACT: Eight new fasamycin-type polyketides, streptovertimycins A-H (1-8), were isolated from soil-derived Streptomyces morookaense SC1169 cultivated on wheat grains. Their structures were established by extensive spectroscopic analysis and theoretical computations of ECD spectra. Compounds 1-8 have a fasamycin-type pentacyclic structure featuring a 15-O-methyl group. They exhibited potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values in the range of 0.63-5.0 μg/ml. The activity profile provided new insights into the structure-activity relationships of fasamycin-type antibiotics.

SUBMITTER: Yang L 

PROVIDER: S-EPMC7223045 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature