Gut microbiota in neonates with congenital gastrointestinal surgical conditions: a prospective study.

ABSTRACT:

Background

There is limited information on gut microbiota of neonates with congenital gastrointestinal surgical conditions (CGISCs) available.

Methods

This study compared stool microbiota and short-chain fatty acids (SCFAs) of 37 term infants with CGISCs with 36 term healthy infants (HIs). Two stool samples were collected from each infant: as soon as possible after birth (week 1) and 10-14 days of life (week 2).

Results

Bacterial richness and alpha diversity were comparable between CGISCs and HIs at week 1 and week 2 (all p > 0.05). Beta diversity analysis revealed that at week 1, CGISCs had similar community structures to HIs (p = 0.415). However, by week 2, community structures of CGISCs were significantly different from HIs (p = 0.003). At week 1, there were no sig

SUBMITTER: Rao SC 

PROVIDER: S-EPMC7223116 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature