Characterization of 100 extended major histocompatibility complex haplotypes in Indonesian cynomolgus macaques.

ABSTRACT: Many medical advancements-including improvements to anti-rejection therapies in transplantation and vaccine development-rely on preclinical studies conducted in cynomolgus macaques (Macaca fascicularis). Major histocompatibility complex (MHC) class I and class II genes of cynomolgus macaques are orthologous to human leukocyte antigen complex (HLA) class I and class II genes, respectively. Both encode cell-surface proteins involved in cell recognition and rejection of non-host tissues. MHC class I and class II genes are highly polymorphic, so comprehensive genotyping requires the development of complete databases of allelic variants. Our group used PacBio circular consensus sequencing of full-length cDNA amplicons to characterize MHC class I and class II transcript sequences for a cohort of

SUBMITTER: Shortreed CG 

PROVIDER: S-EPMC7223175 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature