Association of cathepsin B and cystatin C with an age-related pulmonary subclinical state in a healthy Chinese population.

ABSTRACT:

Background

Cathepsin B (CTSB) and cystatin C (CYSC) are new biomarkers for several physiological and pathological processes as their activities increase with age. The aim of this study was to explore population-level associations between serum CTSB and CYSC with an age-related pulmonary subclinical state.

Methods

We examined 401 healthy participants (aged 36-87 years, of which 44.3% were male) in northern Chinese cities. We used a standard spirometer to determine lung function. Serum CTSB and CYSC levels were measured by enzyme-linked immunosorbent assay (ELISA).

Results

For all participants, serum CTSB was related to maximum vital capacity (VC MAX), forced vital capacity (FVC), forced expiratory volume in 1 s, peak expiratory flow, forced expiratory flow at 25% of FV

SUBMITTER: Wang N 

PROVIDER: S-EPMC7223214 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature